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KMID : 0378019910340120081
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New Medical Journal
1991 Volume.34 No. 12 p.81 ~ p.86
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Clinical Effecacy of Lomefoxacin in the Treatment of Acute Exacerbations of Chronic Bronchitis
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Abstract
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Lomefloxacin, a new difluorinated quinolone, has a good activity against a broad spectrum of both .gram postive and negative, pathogens, is clinically well tolerated,: and has a long half-life which allows for effective once a day dosing.
The objective of this ,study was to evaluate the efficacy and safety of lomefloxacin (400mg) administered orally once a day for 7 days in adult patient with acute exacerbation of chronic bronchitis caused by gram negative bacteria. In vitro sensitivity test was also performed on the bacteria cultured from expectoracted sputum.
Total 43 patients (male : 25 cases, female : 18 cases) could evaluated according to the change of clinical symptom scores. The adverse reactions were estimated by hematologic, biochemical and clinical findings.
The results were as follows
1. There was a significant improvement clinically in fever, cough, dyspnea and sputum (color and numbers of PMN cells) after treatment with lomefloxacin (P<0.005). The efficacy rate was 86%.
2. In vitro sensitivity test, the rate of susceptibility of the isolated bacteria to lomefloxacin was 81%.
3. There was no premature withdrawal of treatment because some adverse reactions (epigastric distress, nausea, diarrhea and headache) to this drug were only mild and transient.
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KEYWORD
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